Simulation-Based Sequential Bayesian Design

Peter Mueller, Don Berry, Andy Grieve, Michael Smith and Michael Krams

August 1999

We consider simulation-based methods for exploration and maximization of expected utility in sequential decision problems. We consider problems which require backward induction with analytically intractable expected utility integrals at each stage. We propose to use forward simulation to approximate the integral expressions, and a reduction of the allowable action space to avoid problems related to an exponentially increasing number of possible trajectories in the backward induction. The artificially reduced action space allows strategies to depend on the full history of earlier observations and decisions only indirectly through a low dimensional summary statistic. We illustrate the proposed approach with an application to an optimal stopping problem in a clinical trial.


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